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A consequence of p-JNK translocation into the mitochondria is that it provides a second hint that amplifies oxidative stress and promotes MPT formation (75)
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Despite the fact that the dimeric macrocycles tightly bind to the ectodomain of human Met and induce various cellular responses in human cells, they did not show any binding activity to that of murine or canine Met (Supplementary Table 3 and Supplementary Fig
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