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Abbreviations ALDH aldehyde dehydrogenase AChE acetylcholine esterase AD Alzheimer’s disease BCL-2 B cell lymphoma protein 2 BTK Bruton’s tyrosine kinase BCR B cell antigen receptor BID twice daily BACE1 β-site amyloid precursor protein cleaving enzyme 1 BMPs bone morphogenetic proteins CCL chronic lymphocytic leukemia ChK1 checkpoint kinase 1 CNS central nervous system CTSS Cathepsin S DLK dual leucine zipper kinase DRG dorsal root ganglion EZH2 enhancer of zeste homolog 2 eIF4E translation initiation factor 4E FDA Food and Drug Administration FLT3 FMS-like tyrosine kinase 3 FKBP12 12-kDa FK506-binding protein GLP-1R glucagon-like peptide-1 receptor GSH glutathione GST glutathione S-transferase hERG human ether-a-go-go related gene HCV hepatitis C virus HFL-1 human fibroblast cell line-1 HD Huntington disease IDO1 Indoleamine 2,3-dioxygenase 1 LRRK2 Leucine-rich repeat kinase 2 MMP-13 matrix metalloproteinase 13 mTOR mammalian target of rapamycin MCL mantle cell lymphoma MCHr1 melanin concentrating hormone receptor 1 mEH microsomal epoxide hydrolase P-gp P-glycoprotein PK pharmacokinetic pHH3 phosphorylation of histone H3 PRC2 polycomb repressive 2 PDGFR platelet-derived growth factor receptor PI3K phosphatidylinositol-3-kinase PHGDH phosphoglycerate dehydrogenase PRMT protein arginine methyltransferase PKC θ Protein kinase C θ PBMCs peripheral blood mononuclear cells PD Parkinson’s disease QD once daily RSV respiratory syncytial virus RA rheumatoid arthritis SCLC small cell lung cancer SYK spleen tyrosine kinase SAR structure-activity relationship TDI time-dependent inhibition TNIK traf2 and Nck-interacting kinase T2DM type 2 diabetes mellitus Vss volume of distribution WB whole blood Footnotes Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper