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In a study, a novel EIF2AK4 splice site mutation was identified alongside a BMPR2 mutation in family members with autosomal dominantly inherited HPAH, supporting a “second hit” model
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There are conflicting recommendations [48] [50] regarding whether to change the dosing of oral acetylcysteine after the administration of activated carbon, and even whether the dosing of acetylcysteine needs to be altered at all
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