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[,,,] The liver-derived coagulation factor XI (FXI) protects against heart failure with preserved ejection fraction, FXI cleaves the precursor BMP7 bound to the extracellular matrix in the heart, this then releases the active form of BMP7 from matrix to bind to BMP receptor and activates transcription factors SMAD1/5 in the heart, thus inhibiting the expression of genes involved in inflammation and fibrosis in the heart
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