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In the leuprolide arm of this study, however, there was an initial increase in LH and FSH, and FSH levels never fell as much as in the degarelix arms 36

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The authors aimed to evaluate the clinical efficacy of prolotherapy with 5% dextrose in water (D5W) injected into the multifidus muscle, versus mechanical needling combined with sterile water injection administered into multiple posterior lumbar structures, including facet joints, medial branches, and multifidus muscle [63]