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Agmatine was able to attenuate the increased glutamate levels due to chronic opioid administration.[ref] Agmatine also helps with neuropathic pain by blocking NMDA glutamate receptors.[ref] Related article: Agmatine supplements for neuropathy and mood Riboflavin (vitamin B2): Riboflavin can reduce the release of glutamate from nerve terminals.[ref] This may be why riboflavin is effective in preventing migraines in some people.[ref] Related article: Riboflavin genes Saffron: A review of animal studies found that saffron “appears to be able to regulate glutamate levels, reduce oxidative stress, and modulate Aβ and tau protein aggregation.”[ref] Related article: Saffron extract N-acetylcysteine (NAC): NAC has been shown to reduce neuronal glutamate release