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These cohorts serve as compelling examples of the lack of direct GH counter-regulatory effects on pancreatic β-cell insulin secretion, thus implying that circulating insulin exerts its glucose-lowering effects more efficiently in these subjects compared with healthy controls

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This work was supported by the Institut National de la Santé et de la Recherche Médicale, the Centre National de la Recherche Scientifique, the FEDER (Fonds Européens de Développement Régional) and the ‘Contrat de plan Etat région Bretagne’ (axe biothérapie)