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Notably, TMAO also amplifies ERS markers such as heat shock protein 60 and glucose regulated protein 78kD in macrophages, correlating with elevated toll-like receptor 4 expression and proinflammatory cytokine production (e.g., TNF-α, IL-6) (88, 89)
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Sakai E, Morita M, Ohuchi M, Kido MA, Fukuma Y, Nishishita K, et al
It naturally occurs in red meat and other animal source foods
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