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For clarity, qualitative descriptors of evidence strength (such as shown in Figures 1, 6) used in this review are defined as follows and are intended to aid interpretation across heterogeneous study designs rather than imply formal clinical grading: Strong in vitro evidence: reproducible effects shown in ≥2 independent studies using quantitative, standardized assays (e.g., MIC, time–kill, biofilm or quorum-sensing assays) across multiple microbial strains or species

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Peptide Regulation Debate Intensifies After FDA Advisory Panel's Controversial Vote Habiba Atta Laura Joszt, MA Key Takeaways FDA movement of peptides toward 503A bulks listing advanced despite internal scientific objections citing absent human clinical evidence for most nominees and highlighting regulatory governance tensions

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