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3.2.2.1 Basic science research In animal models of PD, GIP analogs showed promising results with improvement in motor symptoms and reduction of the inflammation response (Vaccari et al., 2021)An extensive systematic review and meta-analysis including preclinical studies on the effects of GLP-1 agonists, DPP-4 inhibitors, and dual GLP-1/GIP agonists on NBD, found that liraglutide (Turnes et al., 2018), tested on moderate to severe DA-ergic neuron loss, were not effective in reversing the effects of 6-OHDA on DA-ergic neurons and associated behaviors
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