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All the hydroxylase enzymes are cytochrome P450 mixed-function oxidases (CYPs) [34], located either in the endoplasmic reticulum (ER) or in the mitochondria [33]
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An increase in the activity of GSK3β has been observed in the prefrontal cortex of patients and suicide victims with depression ( in vitro experiments showed that EGCG enhanced the survival of A549 cells via activation of AKT ( CRMP2, a phosphorylation target of GSK3β, has been implicated in various models of depression induced by stress ( In conclusion, we demonstrated for the first time that PPD is associated with elevated expression of Sema3A and decreased phosphorylation of GSK3β in the hippocampus
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