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Loose iron is relatively abundant (20โ60 micromolar) inside bacterial cytoplasms (Keyer and Imlay, 1996
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For instance, in oncology, 53.3% of new drugs developed between 1946 and 1980 were either natural products or derivatives thereof, with a reduced but still significant proportion of 33.5% from 1981 to the present (Newman and Cragg, 2020)
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