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This, in turn, activates many downstream signaling pathways, such as the three mitogen‑activated protein kinase (MAPK) pathways, including extracellular signal‑regulated kinase 1/2 (ERK1/2), Jun amino‑terminal kinase (JNK), and p38 MAPK pathways, as well as signal transducer and activator of transcription 3 (STAT3), nuclear factor kappa B (NF‑κB), phosphatidylinositol 3‑kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR), Rho‑like GTPase, and SRC/focal adhesion kinase (SRC/FAK) cascades 86,87,89,90
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