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Additionally, Paneth cells lacking Atg16L1 , Atg5 , or Atg7 showed impaired secretion of antimicrobial proteins, which confer intestinal protection against pathogens [105]
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Low temperatures accelerate metHb denaturation, releasing free hemin or heme and forming hemichromes (Samuel et al., 2020), which tightly bind to the membrane, increasing rigidity, promoting removal signals, like band three aggregates (Badior and Casey, 2018), and disrupting phosphorylation events (Pantaleo et al., 2016)
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