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98 investigated the effects of denosumab on osteoclast activity and chondrocyte apoptosis in OA patients and found that denosumab effectively inhibited RANKL-induced osteoclastogenesis by blocking the RANK/RANKL signaling pathway via competitive bidding to RANKL
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further validated the efficacy of BHD in rescuing the infarct area and blood-brain barrier permeability with the use of a rat model
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