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The risk is not only the sequence Even where a molecule is biologically plausible, the product introduces a second layer of risk such as sterility and endotoxin contamination, incorrect peptide identity or concentration, degradation during storage, aggregation and immunogenicity, synthesis-related impurities, injection-site infection or granuloma, unpredictable systemic exposure and an absence of long-term carcinogenicity and reproductive data

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9 However, while D-retro-inversed proteins fold into the same structures as the L-forms, and have comparable stabilities, there are differences, for instance, in helix-winding