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Melanocortin receptor agonists Cleavage of POMC produces, among other peptides, α-MSH, which activates melanocortin 3 and 4 receptors (Mc3r, Mc4r) to exert catabolic effects [54]
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qRT-PCR analysis revealed that MEP administration significantly increased ASK1 expression in brain tissue compared to the control group, reflecting activation of oxidative and pro-apoptotic pathways through ASK1 induction
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