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2013, J Pharmacol Exp Ther β the foundational dihexa paper and the source of nearly every dose, half-life and spine-density number in circulation
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Taken together, the metabolic synergy between disulfidptosis and ferroptosis, cuproptosis, pyroptosis, as well as ER stressβrelated pathways, can be viewed as a regulatory network organized around the βcystineβGSHβNADPHβ metabolic axis
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