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And the zeta-potential measured by the Nano Sizer and Zeta-potential analyzer of LNPs were determined to be 6.00±0.07 mV, while BUD-LNPs had a zeta-potential of 3.33±0.13 mV (Figure 2d), which enhanced their interaction with the negatively charged mucus network and facilitated their penetration and retention in the lungs
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