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These tests support membrane permeability and are consistent with the later rat oral-bioavailability result

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AOD9604 vs Intact hGH in Obesity Models A direct head-to-head comparison of AOD9604 and intact hGH in obese and lean mice confirmed that both compounds significantly reduced body weight gain in obese animals through increased fat oxidation and lipolysis stimulation — but that AOD9604 achieved this without the hGH receptor binding, IGF-1 stimulation, hyperglycaemia, or reduced insulin secretion associated with full-length hGH treatment

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