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NAD+ is the coenzyme behind cellular redox reactions and sirtuin activity, 5-Amino-1MQ is studied as an NNMT inhibitor that helps preserve the NAD+ salvage pathway in research models, and MOTS-c is a mitochondrial-derived peptide linked to AMPK activation and metabolic homeostasis (Lee et al., 2015, Cell Metabolism)
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The non-targeted or pLKO.1-shGPX4 lentiviral particles were transiently transduced into K1 cells
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