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Although ARE/EpRE, AP-1 and NFκB may be responsible for basal expression and induction of GCLC by many of the pro- and anti-oxidants, recently c-Myc has been identified to also contribute to the basal expression and induction of human GCL under oxidative stress (Benassi et al., 2006)

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Particular sphincters (lower esophageal sphincter, pyloric sphincter [107,108,109,110,111,112,113,114,115], pupil [73,116], urinary sphincter [91,117,118]) with distinctive functions, are all affected in the same way during conditions of sickness and the recovery of disabled function