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A possible explanation for unexpected or contrasting observations is that forcing the plant to overproduce PCs caused a severe GSH depletion, which disables GSH in fulfilling its other important functions in antioxidative defense and signaling

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Moreover, hyperinsulinemia, a phenomenon associated with insulin resistance, results in high levels of insulin and glucose in blood, leading to an increase in the release of proinflammatory cytokines, promoting microglial proliferation and proinflammatory polarization in vivo (Yang et al., 2022)