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1901-A CELL-FREE NUCLEIC ACIDS VARY BY DISEASE SEVERITY AND BODY COMPARTMENTALIZATION IN CHRONIC HEPATITIS C VIRUS INFECTION Nicole San-Dee Minerva 1 , Rownock Afruza 1 , Christina Park 2 , Moumita Chakraborty 1 , Adekanyinsola Onitiri 1 , Maleeha F Ahmad 1 , Rabab Ali 1 , Elliott Levy 3 , Ohad Etzion 1 , David E Kleiner 4 , Christopher Koh 5 and Theo Heller 1 , (1)Translational Hepatology Section, National Institutes of Health, (2)Clinical Research Section, National Institutes of Health, (3)Radiology & Imaging Sciences Department, National Institutes of Health, (4)Laboratory of Pathology, National Cancer Institute, National Institutes of Health, (5)National Institute of Diabetes and Digestive and Kidney Diseases, Nih Background: Circulatory cell-free nucleic acids (ccfNAs), comprised of both ccfDNAs and ccfRNAs, play roles in signaling, immunity, and gene regulation

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