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Studies have also shown that treatment with ALA can decrease acute kidney injury by lowering serum blood urea nitrogen, creatinine levels, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β), thereby decreasing endothelin-1 vasoconstriction, neutrophil diffusion, and inflammation in the kidneys
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Given the highly inflammatory and infectious nature of osteomyelitis, and the pathogen-triggered integration of pyroptosis, apoptosis, and necroptosis within PANoptosis, the formation of PANoptosome-like complexes is likely involved in orchestrating cell death in this disease context
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