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10.1038/cdd.2016.7 Cell Death Differ
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Rearrangement of PDGFRB (most commonly EBF1 :: PDGFRB ), commonly associated with the BCR :: ABL1 -like subtype.[153,156] These patients represent less than 1% of B-ALL cases in children but account for as much as 10% of induction failure cases.[153] In one retrospective study, 43 of 49 patients (88%) with PDGFRB fusions had EOI MRD levels greater than 1%.[157] In a large retrospective study, the OS rate of patients with induction failure was only 32%.[151] However, there was significant clinical and biological heterogeneity
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