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One compelling histopathological correlate of disability progression is the “slowly-expanding lesion,” characterized by a presumably “inactive” gliotic demyelinated center surrounded by a rim of activated microglia and macrophages containing degenerated myelin, injured axons and often iron deposition (Dal-Bianco et al., 2017

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Instead, it is understood as a disorder of how the nervous system processes pain, where normal sensory input is amplified and interpreted as pain due to a process known as central sensitization