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In the group treated with 150 mg/kg of rutin nanoformulation, there was mild to moderate inflammatory infiltration, moderate focal ulceration and necrosis, and moderate edema and hyperemia in the mucosa, submucosa, and muscularis layers, along with a more organized epithelial structure and crypt architecture
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Incorporating these sophisticated analytical approaches into early-phase clinical trials may facilitate the identification of patient cohorts most likely to benefit from ferroptosis-targeted interventions
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