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To address this in an unbiased way, we profiled cellular metabolites of activated CD8 + T cells after treatment with A2AR inhibition using a selective A2AR antagonist, SCH58261 (A2ARi), by liquid chromatography–mass spectrometry (LC-MS)
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Post-mortem analysis indicates a decrease in the BDNF level in the hippocampus [223] and distinct cortical areas [224] of depressed patients, as well as in prefrontal cortex and hippocampus of suicide victims [225]
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