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Consistent with this, we found that hepatic GSH level fell more than 50% following LPS, coinciding with a comparable fall in the mRNA and protein levels of GCLC and GCLM (50–60%) [163]
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A pharmacokinetic study in rats found that oral administration produced substantial plasma concentrations, with a maximum concentration of 2252 ng/mL and an elimination half-life of approximately 6.9 hours
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